Cystatin A

CSTA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CYU, 1CYV, 1DVC, 1DVD, 1GD3, 1GD4, 1N9J, 1NB3, 1NB5, 3K9M, 3KFQ, 3KSE
Identifiers
Aliases	CSTA, AREI, STF1, STFA, Cystatin A, PSS4
External IDs	OMIM: 184600; MGI: 1924020; HomoloGene: 3819; GeneCards: CSTA; OMA:CSTA - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	122,341,969 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,077,810 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; oral cavity; ; gums; ; gingival epithelium; ; body of tongue; ; human penis; ; vulva; ; superior surface of tongue; ; epithelium of nasopharynx; ; skin of thigh;
	Top expressed in
	granulocyte; ; zygote; ; morula; ; blastocyst; ; blood; ; right kidney; ; proximal tubule; ; suprachiasmatic nucleus; ; secondary oocyte; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protease binding; protein-macromolecule adaptor activity; endopeptidase inhibitor activity; structural molecule activity; cysteine-type endopeptidase inhibitor activity;
Cellular component	cytoplasm; intracellular anatomical structure; cornified envelope; extracellular space; nucleus; cytosol;
Biological process	negative regulation of proteolysis; peptide cross-linking; negative regulation of peptidase activity; cell adhesion; keratinocyte differentiation; negative regulation of endopeptidase activity; cornification; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1475
	76770
	ENSG00000121552
	ENSMUSG00000095620
	P01040
	Q9D8D6
	NM_005213
	NM_029733; NM_001384090
	NP_005204
	NP_084009; NP_001371019
	Wikidata
View/Edit Human	View/Edit Mouse

Cystatin-A is a protein that in humans is encoded by the CSTA gene.

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.