CTAG1B

CTAG1B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1S9W, 2BNQ, 2BNR, 2F53, 2F54, 2P5E, 2P5W, 2PYE, 3GJF, 3HAE, 3KLA
Identifiers
Aliases	CTAG1B, CT6.1, CTAG, CTAG1, ESO1, LAGE-2, LAGE2B, NY-ESO-1, cancer/testis antigen 1B
External IDs	OMIM: 300156; HomoloGene: 133254; GeneCards: CTAG1B; OMA:CTAG1B - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,619,282 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; left testis; ; right testis; ; stromal cell of endometrium; ; muscle of thigh; ; ectocervix; ; primary visual cortex; ; skeletal muscle tissue; ; lactiferous gland;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	1485
	n/a
	ENSG00000184033
	n/a
	P78358
	n/a
	NM_001327
	n/a
	NP_640343; NP_001318
	n/a
	Wikidata
View/Edit Human

Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene. It is most often referenced by its alias NY-ESO-1.

Cancer/Testis Antigen 1B is a protein belonging to the family of Cancer Testis Antigens (CTA) that are expressed in a variety of malignant tumours at the mRNA and protein levels, but also restricted to testicular germ cells in normal adult tissues. A clone of CTAG gene was originally identified by immunological methods in oesophageal carcinoma using patient serum. The aberrant re-expression of CTAs is induced by molecular mechanisms including DNA demethylation, histone post-translational modification, and microRNA-mediated regulation. The effect of DNA demethylation is evident by the capability of demethylating agents, such as 5-aza-2-deoxycytidine, to induce CTAs re-expression in tumour cells but not in normal epithelial cells.