Catenin alpha-1

CTNNA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H6G, 4EHP, 4IGG
Identifiers
Aliases	CTNNA1, CAP102, Catenin, MDPT2, catenin alpha 1
External IDs	OMIM: 116805; MGI: 88274; HomoloGene: 1433; GeneCards: CTNNA1; OMA:CTNNA1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	138,935,034 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	35,387,832 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; Achilles tendon; ; amniotic fluid; ; nasal epithelium; ; corpus callosum; ; tibial nerve; ; middle frontal gyrus; ; mucosa of pharynx; ; bronchial epithelial cell; ; ventricular zone;
	Top expressed in
	medullary collecting duct; ; endothelial cell of lymphatic vessel; ; ciliary body; ; conjunctival fornix; ; retinal pigment epithelium; ; Paneth cell; ; Epithelium of choroid plexus; ; iris; ; left lung lobe; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	gamma-catenin binding; actin filament binding; beta-catenin binding; protein binding; vinculin binding; structural molecule activity; protein heterodimerization activity; RNA binding; cadherin binding; identical protein binding;
Cellular component	acrosomal vesicle; cytoskeleton; intracellular membrane-bounded organelle; intercalated disc; actin cytoskeleton; adherens junction; catenin complex; cytosol; membrane; plasma membrane; cytoplasm; cell-cell junction; cell junction; lamellipodium; Golgi apparatus; focal adhesion; zonula adherens; flotillin complex;
Biological process	positive regulation of smoothened signaling pathway; actin filament organization; response to estrogen; regulation of cell population proliferation; response to organic cyclic compound; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuroblast proliferation; establishment or maintenance of cell polarity; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; gap junction assembly; negative regulation of cell motility; negative regulation of integrin-mediated signaling pathway; apical junction assembly; cell adhesion; ageing; male gonad development; protein heterooligomerization; adherens junction organization; positive regulation of muscle cell differentiation; ovarian follicle development; odontogenesis of dentin-containing tooth; cellular response to indole-3-methanol; negative regulation of apoptotic process; axon regeneration; epithelial cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1495
	12385
	ENSG00000044115
	ENSMUSG00000037815
	P35221
	P26231
NM_001290307; NM_001290309; NM_001290310; NM_001290312; NM_001903;
	NM_001323982; NM_001323983; NM_001323984; NM_001323985; NM_001323986; NM_001323987; NM_001323988; NM_001323989; NM_001323990; NM_001323991; NM_001323992; NM_001323993; NM_001323994; NM_001323995; NM_001323996; NM_001323997; NM_001323998; NM_001323999; NM_001324000; NM_001324001; NM_001324002; NM_001324003; NM_001324004; NM_001324005; NM_001324006; NM_001324007; NM_001324008; NM_001324009; NM_001324010; NM_001324011; NM_001324012; NM_001324013
	NM_009818
NP_001277236; NP_001277238; NP_001277239; NP_001277241; NP_001310911;
	NP_001310912; NP_001310913; NP_001310914; NP_001310915; NP_001310916; NP_001310917; NP_001310918; NP_001310919; NP_001310920; NP_001310921; NP_001310922; NP_001310923; NP_001310924; NP_001310925; NP_001310926; NP_001310927; NP_001310928; NP_001310929; NP_001310930; NP_001310931; NP_001310932; NP_001310933; NP_001310934; NP_001310935; NP_001310936; NP_001310937; NP_001310938; NP_001310939; NP_001310940; NP_001310941; NP_001310942; NP_001894; NP_001277236.1
	NP_033948
	Wikidata
View/Edit Human	View/Edit Mouse

αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it functions to mediate the anchorage of actin filaments to the sarcolemma. αE-catenin also plays a role in tumor metastasis and skin cell function.