CTP synthase 1

CTPS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VO1
Identifiers
Aliases	CTPS1, CTPS, IMD24, CTP synthase 1, GATD5
External IDs	OMIM: 123860; MGI: 1858304; HomoloGene: 20446; GeneCards: CTPS1; OMA:CTPS1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	41,012,565 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	120,427,473 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; ascending aorta; ; left uterine tube; ; right coronary artery; ; left coronary artery; ; gonad; ; body of uterus; ; popliteal artery; ; tibial arteries; ; muscle layer of sigmoid colon;
	Top expressed in
	hair follicle; ; primitive streak; ; primary oocyte; ; superior cervical ganglion; ; mandibular prominence; ; somite; ; maxillary prominence; ; endothelial cell of lymphatic vessel; ; endocardial cushion; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ligase activity; ATP binding; CTP synthase activity; identical protein binding;
Cellular component	cytosol; membrane; cytoplasm; cytoophidium;
Biological process	T cell proliferation; B cell proliferation; nucleobase-containing small molecule interconversion; glutamine metabolic process; nucleobase-containing compound metabolic process; 'de novo' CTP biosynthetic process; pyrimidine nucleotide biosynthetic process; immune system process; CTP biosynthetic process; pyrimidine nucleobase biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1503
	51797
	ENSG00000171793
	ENSMUSG00000028633
	P17812
	P70698
	NM_001301237; NM_001905
	NM_016748; NM_001355491
	NP_001288166; NP_001896
	NP_058028; NP_001342420
	Wikidata
View/Edit Human	View/Edit Mouse

CTP synthase 1 is an enzyme that is encoded by the CTPS1 gene in humans. CTP synthase 1 is an enzyme in the de novo pyrimidine synthesis pathway that catalyses the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP). CTP is a key building block for the production of DNA, RNA and some phospholipids.