Cathepsin B

CTSB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PBH, 1CSB, 1GMY, 1HUC, 1PBH, 2IPP, 2PBH, 3AI8, 3CBJ, 3CBK, 3K9M
Identifiers
Aliases	CTSB, APPS, CPSB, cathepsin B, RECEUP
External IDs	OMIM: 116810; MGI: 88561; HomoloGene: 37550; GeneCards: CTSB; OMA:CTSB - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	11,869,448 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	63,383,372 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; appendix; ; canal of the cervix; ; gallbladder; ; ectocervix; ; smooth muscle tissue; ; olfactory zone of nasal mucosa; ; monocyte;
	Top expressed in
	stroma of bone marrow; ; calvaria; ; white adipose tissue; ; subcutaneous adipose tissue; ; epithelium of stomach; ; brown adipose tissue; ; tibiofemoral joint; ; tunica adventitia of aorta; ; decidua; ; lactiferous gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; collagen binding; peptidase activity; protein binding; cysteine-type endopeptidase activity; hydrolase activity; proteoglycan binding; serine-type endopeptidase activity; endopeptidase activity;
Cellular component	intracellular membrane-bounded organelle; melanosome; intracellular anatomical structure; extracellular region; endolysosome lumen; nucleolus; mitochondrion; lysosome; extracellular exosome; perinuclear region of cytoplasm; extracellular space; ficolin-1-rich granule lumen; collagen-containing extracellular matrix;
Biological process	regulation of apoptotic process; epithelial cell differentiation; proteolysis; toll-like receptor signaling pathway; decidualization; cellular response to thyroid hormone stimulus; collagen catabolic process; viral entry into host cell; regulation of catalytic activity; proteolysis involved in cellular protein catabolic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1508
	13030
	ENSG00000164733; ENSG00000285132
	ENSMUSG00000021939
	P07858
	P10605
NM_001908; NM_147780; NM_147781; NM_147782; NM_147783;
	NM_001317237
	NM_007798
NP_001304166; NP_001899; NP_680090; NP_680091; NP_680092;
	NP_680093
	NP_031824
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis. In humans, cathepsin B is encoded by the CTSB gene. Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions.