Cathepsin L2

CTSV
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FH0, 3H6S, 3KFQ
Identifiers
Aliases	CTSV, cathepsin V, CATL2, CTSL2, CTSU
External IDs	OMIM: 603308; MGI: 88564; HomoloGene: 76699; GeneCards: CTSV; OMA:CTSV - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	97,156,556 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	64,518,704 bp
RNA expression pattern
	Top expressed in
	thymus; ; skin of arm; ; skin of thigh; ; oocyte; ; retinal pigment epithelium; ; amniotic fluid; ; secondary oocyte; ; hair follicle; ; vulva; ; gonad;
	Top expressed in
	stroma of bone marrow; ; iris; ; epithelium of lens; ; decidua; ; endothelial cell of lymphatic vessel; ; gastrula; ; corneal stroma; ; ciliary body; ; efferent ductule; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; peptide binding; peptidase activity; protein binding; aminopeptidase activity; hydrolase activity; serine-type endopeptidase activity; cysteine-type endopeptidase activity; cysteine-type carboxypeptidase activity; histone binding; kininogen binding; protein-containing complex binding;
Cellular component	cytoplasm; perikaryon; apical part of cell; secretory granule; extracellular region; microvillus; vacuole; lysosomal lumen; neuron projection; lysosome; external side of plasma membrane; extracellular space; nucleus; nucleolus; cytoplasmic vesicle;
Biological process	male gonad development; response to organic cyclic compound; antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to starvation; extracellular matrix disassembly; response to glucocorticoid; response to glucose; Sertoli cell differentiation; response to gonadotropin; proteolysis; cell communication; decidualization; spermatogenesis; multicellular organism aging; proteolysis involved in cellular protein catabolic process; nerve development; autophagic cell death; response to odorant; regulation of keratinocyte differentiation; negative regulation of keratinocyte proliferation; protein processing; protein autoprocessing; hair follicle morphogenesis; regulation of actin cytoskeleton reorganization;
	Sources:Amigo / QuickGO
Orthologs
	1515
	13039
	ENSG00000136943
	ENSMUSG00000021477
	O60911
	P06797
	NM_001333; NM_001201575
	NM_009984
	NP_001188504; NP_001324
	NP_034114
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin L2 (EC 3.4.22.43, also known as cathepsin V or cathepsin U) is a protein encoded in humans by the CTSV gene.

The protein is a human cysteine cathepsin, a lysosomal cysteine protease with endopeptidase activity.

The protein is a member of the papain-like protease family (MEROPS family C1), a lysosomal cysteine protease with endopeptidase activity. It may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.