Cathepsin W

CTSW
Identifiers
Aliases	CTSW, LYPN, cathepsin W
External IDs	OMIM: 602364; MGI: 1338045; HomoloGene: 37471; GeneCards: CTSW; OMA:CTSW - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,883,741 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,518,535 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; bone marrow cells; ; spleen; ; decidua; ; mononuclear cell; ; monocyte; ; lymph node; ; upper lobe of left lung; ; right lung;
	Top expressed in
	mesenteric lymph nodes; ; blood; ; thymus; ; spleen; ; embryo; ; subcutaneous adipose tissue; ; pharynx; ; duodenum; ; embryo; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity;
Cellular component	lysosome; membrane; platelet dense granule lumen; extracellular region; extracellular space; endoplasmic reticulum;
Biological process	proteolysis involved in cellular protein catabolic process; immune response; proteolysis; platelet degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1521
	13041
	ENSG00000172543
	ENSMUSG00000024910
	P56202
	P56203
	NM_001335
	NM_009985
	NP_001326
	NP_034115
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin W is a protein that in humans is encoded by the CTSW gene.

The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the cell membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.