Cathepsin Z

CTSZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DEU, 1EF7
Identifiers
Aliases	CTSZ, CTSX, cathepsin Z
External IDs	OMIM: 603169; MGI: 1891190; HomoloGene: 1022; GeneCards: CTSZ; OMA:CTSZ - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	59,008,238 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	174,280,832 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; mucosa of transverse colon; ; right coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; rectum; ; upper lobe of left lung; ; right lobe of liver; ; right lung;
	Top expressed in
	stroma of bone marrow; ; yolk sac; ; dermis; ; left lung lobe; ; migratory enteric neural crest cell; ; calvaria; ; decidua; ; supraoptic nucleus; ; parotid gland; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; peptidase activity; hydrolase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; carboxypeptidase activity;
Cellular component	endoplasmic reticulum lumen; COPII-coated ER to Golgi transport vesicle; intracellular membrane-bounded organelle; endoplasmic reticulum; plasma membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular exosome; Golgi membrane; extracellular region; specific granule lumen; ficolin-1-rich granule lumen; extracellular space; lysosome; cell surface; growth cone; cytoplasmic vesicle; cell cortex region; collagen-containing extracellular matrix;
Biological process	proteolysis involved in cellular protein catabolic process; COPII vesicle coating; endoplasmic reticulum to Golgi vesicle-mediated transport; epithelial tube branching involved in lung morphogenesis; angiotensin maturation; neutrophil degranulation; proteolysis; negative regulation of plasminogen activation; negative regulation of neuron projection development; negative regulation of protein binding; positive regulation of neuron apoptotic process; regulation of neuron death; positive regulation of neural precursor cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1522
	64138
	ENSG00000101160
	ENSMUSG00000016256
	Q9UBR2
	Q9WUU7
	NM_001336
	NM_022325
	NP_001327
	NP_071720
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin Z, also called cathepsin X or cathepsin P, is a protein that in humans is encoded by the CTSZ gene. It is a member of the cysteine cathepsin family of cysteine proteases, which has 11 members. As one of the 11 cathepsins, cathepsin Z contains distinctive features from others. Cathepsin Z has been reported involved in cancer malignancy and inflammation.