Cortactin

CTTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X69, 2D1X
Identifiers
Aliases	CTTN, EMS1, cortactin
External IDs	OMIM: 164765; MGI: 99695; HomoloGene: 3834; GeneCards: CTTN; OMA:CTTN - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	70,436,584 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,024,746 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; body of uterus; ; left ovary; ; right ovary; ; right adrenal cortex; ; myometrium; ; gastric mucosa; ; right uterine tube; ; canal of the cervix; ; left adrenal cortex;
	Top expressed in
	medullary collecting duct; ; transitional epithelium of urinary bladder; ; gastrula; ; endothelial cell of lymphatic vessel; ; cumulus cell; ; calvaria; ; Paneth cell; ; epithelium of stomach; ; renal corpuscle; ; tail of embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	profilin binding; protein binding; cadherin binding;
Cellular component	cytoplasm; Golgi apparatus; cell projection; intracellular membrane-bounded organelle; membrane; focal adhesion; growth cone; ruffle; voltage-gated potassium channel complex; cortical cytoskeleton; plasma membrane; dendritic spine; mitotic spindle midzone; cell junction; dendrite; cell cortex; actin filament; podosome; clathrin-coated pit; extracellular exosome; cytoskeleton; lamellipodium; cytosol;
Biological process	actin cytoskeleton reorganization; neuron projection morphogenesis; endocytosis; positive regulation of actin filament polymerization; regulation of axon extension; cell motility; substrate-dependent cell migration, cell extension; negative regulation of extrinsic apoptotic signaling pathway; receptor-mediated endocytosis; dendritic spine maintenance; focal adhesion assembly; actin filament polymerization; regulation of autophagy of mitochondrion; lamellipodium organization; intracellular protein transport; positive regulation of smooth muscle contraction; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	2017
	13043
	ENSG00000085733; ENSG00000288401
	ENSMUSG00000031078
	Q14247
	Q60598
	NM_001184740; NM_005231; NM_138565
	NM_001252572; NM_007803; NM_001357116
	NP_001171669; NP_005222; NP_612632
	NP_001239501; NP_031829; NP_001344045
	Wikidata
View/Edit Human	View/Edit Mouse

Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. It is present in all cell types. When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. Cortactin is important in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis.