CXCL17

Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine initially thought to belong to the CXC chemokine family, then addressed as chemokine-like protein, that has been identified in humans and mice.

CXCL17 has been previously reported to attract dendritic cells and monocytes, but there are also studies not reporting this activity; it is also regulated in tumors. It was formerly known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC). This chemokine is constitutively expressed in the respiratory tract and more specifically in the lung. The gene for human CXCL17 is located on chromosome 19. Human and murine CXCL17 protein share 71% of amino acid sequence identity .