CXCL6

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Structures	Swiss-model
Domains	InterPro

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Identifiers
Symbol	CXCL6
Alt. symbols	SCYB6, GCP-2, CKA-3
NCBI gene	6372
HGNC	10643
OMIM	138965
RefSeq	NM_002993
UniProt	P80162
Other data
Locus	Chr. 4 q21
Structures
Search for
Structures	Swiss-model
Domains	InterPro

CXCL6
Identifiers
Aliases	CXCL6, CKA-3, GCP-2, GCP2, SCYB6, C-X-C motif chemokine ligand 6
External IDs	OMIM: 138965; MGI: 1096868; HomoloGene: 88671; GeneCards: CXCL6; OMA:CXCL6 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	73,849,064 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	90,909,483 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; palpebral conjunctiva; ; spleen; ; olfactory zone of nasal mucosa; ; cartilage tissue; ; islet of Langerhans; ; beta cell; ; parietal pleura; ; jejunal mucosa; ; sperm;
	Top expressed in
	right lobe of liver; ; cervix; ; endothelial cell of lymphatic vessel; ; trachea; ; respiratory epithelium; ; olfactory epithelium; ; mandibular molars; ; embryo; ; embryo; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; CXCR chemokine receptor binding; heparin binding; chemokine activity; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	chemotaxis; cell-cell signaling; chemokine-mediated signaling pathway; regulation of cell population proliferation; defense response to bacterium; signal transduction; neutrophil mediated immunity; defense response; positive regulation of neutrophil chemotaxis; neutrophil chemotaxis; neutrophil activation; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; inflammatory response; immune response; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; leukocyte homeostasis; leukocyte chemotaxis; response to lipopolysaccharide; regulation of chemokine production; regulation of neutrophil mediated killing of gram-negative bacterium;
	Sources:Amigo / QuickGO
Orthologs
	6372
	20311
	ENSG00000124875
	ENSMUSG00000029371
	P80162
	P50228
	NM_002993
	NM_009141
	NP_002984
	NP_033167
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.