CXCL9

CXCL9
Identifiers
Aliases	CXCL9, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9
External IDs	OMIM: 601704; MGI: 1352449; HomoloGene: 1813; GeneCards: CXCL9; OMA:CXCL9 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	76,007,509 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,475,938 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; epithelium of nasopharynx; ; superficial temporal artery; ; rectum; ; olfactory zone of nasal mucosa; ; palpebral conjunctiva; ; testicle; ; gallbladder; ; parietal pleura;
	Top expressed in
	subcutaneous adipose tissue; ; mesenteric lymph nodes; ; submandibular gland; ; white adipose tissue; ; spleen; ; left lobe of liver; ; tunica adventitia of aorta; ; brown adipose tissue; ; jejunum; ; mammary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; CXCR3 chemokine receptor binding; chemokine activity; protein binding;
Cellular component	extracellular region; external side of plasma membrane; extracellular space; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; chemokine-mediated signaling pathway; cell-cell signaling; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP-mediated signaling; chemotaxis; positive regulation of leukocyte chemotaxis; cellular defense response; positive regulation of myoblast fusion; response to lipopolysaccharide; regulation of cell population proliferation; positive regulation of myoblast differentiation; defense response to virus; immune response; signal transduction; defense response; inflammatory response; T cell chemotaxis; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; response to bacterium; neutrophil chemotaxis; leukocyte chemotaxis; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	4283
	17329
	ENSG00000138755
	ENSMUSG00000029417
	Q07325
	P18340
	NM_002416
	NM_008599
	NP_002407
	NP_032625
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). The CXCL9 is one of the chemokine which plays role to induce chemotaxis, promote differentiation and multiplication of leukocytes, and cause tissue extravasation.

It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.