Interleukin 8 receptor, alpha

CXCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ILP, 1ILQ, 2LNL
Identifiers
Aliases	CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA, Interleukin 8 receptor, C-X-C motif chemokine receptor 1
External IDs	OMIM: 146929; MGI: 2448715; HomoloGene: 68074; GeneCards: CXCR1; OMA:CXCR1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,166,962 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,233,790 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; periodontal fiber; ; spleen; ; bone marrow; ; bone marrow cells; ; appendix; ; right lung; ; upper lobe of left lung; ; nasal epithelium;
	Top expressed in
	granulocyte; ; blastocyst; ; placenta; ; lung; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; interleukin-8 binding; G protein-coupled receptor activity; chemokine receptor activity; interleukin-8 receptor activity; signal transducer activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; secretory granule membrane; membrane; external side of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; receptor internalization; dendritic cell chemotaxis; signal transduction; chemokine-mediated signaling pathway; interleukin-8-mediated signaling pathway; neutrophil degranulation; chemotaxis; immune response; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; neutrophil chemotaxis; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	3577
	227288
	ENSG00000163464
	ENSMUSG00000048480
	P25024
	Q810W6
	NM_000634
	NM_178241
	NP_000625
	NP_839972
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1. It has also been designated as CD181 (cluster of differentiation 181). The IUPHAR Committee on Receptor Nomenclature and Drug Classification use the HGNC recommended name, CXCR1.