CXXC5

CXXC5
Identifiers
Aliases	CXXC5, CF5, RINF, WID, HSPC195, CXXC finger protein 5
External IDs	OMIM: 612752; MGI: 1914643; HomoloGene: 9517; GeneCards: CXXC5; OMA:CXXC5 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	139,683,882 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	35,994,741 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; renal medulla; ; inferior ganglion of vagus nerve; ; Medulla Oblongata; ; ventral tegmental area; ; superior vestibular nucleus; ; Cerebellum; ; nasal epithelium; ; Pons; ; cerebellar hemisphere;
	Top expressed in
	Epithelium of choroid plexus; ; tail of embryo; ; lens; ; ciliary body; ; iris; ; cerebellar cortex; ; epithelium of lens; ; islet of Langerhans; ; Rostral migratory stream; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; zinc ion binding; transcription factor binding; protein binding; signal transducer activity; metal ion binding;
Cellular component	nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51523
	67393
	ENSG00000171604
	ENSMUSG00000046668
	Q7LFL8
	Q91WA4
NM_016463; NM_001317199; NM_001317200; NM_001317201; NM_001317202;
	NM_001317203; NM_001317204; NM_001317205; NM_001317206; NM_001317207; NM_001317208; NM_001317209; NM_001317210; NM_001317211
	NM_133687; NM_001357458; NM_001357459
NP_001304128; NP_001304129; NP_001304130; NP_001304131; NP_001304132;
	NP_001304133; NP_001304134; NP_001304135; NP_001304136; NP_001304137; NP_001304138; NP_001304139; NP_001304140; NP_057547
	NP_598448; NP_001344387; NP_001344388
	Wikidata
View/Edit Human	View/Edit Mouse

CXXC-type zinc finger protein 5 is a protein that is encoded by the CXXC5 gene in humans.

As indicated by its name, the CXXC5 plays a role as a transcription factor in the nucleus of cells, and involved in myelopoiesis, endothelial differentiation, vessel formation, and oligodendrocyte differentiation.

The CXXC5 is also characterized as a negative feedback regulator of the Wnt/β-catenin signaling pathway functioning by direct interaction with the Dishevelled (Dvl) protein in the cytosol. The cytosolic overexpression of CXXC5 was induced by several pathophysiological conditions, such as osteoporosis, alopecia, senescence of growth plate, cutaneous wound, and restoration of the suppressed Wnt/β-catenin signaling by blockade of its Dvl binding function improved the pathological features as observed in Cxxc5^-/- mice. These results indicate that the Dvl binding with cytosolic CXXC5 could be a target for the development of agents for treating alopecia, acute wound, and short stature in childhood and adolescence, which exhibit suppressed Wnt/β-catenin signaling by cytosolic CXXC5 overexpression of the responsible tissue cells. The CXXC5-Dvl protein-protein interaction (PPI) as a target for development of agents in hair loss or acute wound was also confirmed by construction and testing the function of PTD-DBM, a peptide inhibiting the CXXC5-Dvl PPIl.

The improvement of abnormalities by the CXXC5-Dvl PPI inhibitor is attributed to restoration of damaged tissues by activating the stem cells through restorative activation of the suppressed Wnt/β-catenin signaling and its target genes involving regeneration.