Cytochrome b-245, alpha polypeptide

CYBA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WLP
Identifiers
Aliases	CYBA, p22-PHOX, Cytochrome b-245, alpha polypeptide, cytochrome b-245 alpha chain, CGD4
External IDs	OMIM: 608508; MGI: 1316658; HomoloGene: 80; GeneCards: CYBA; OMA:CYBA - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	88,651,083 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,159,669 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; mucosa of transverse colon; ; spleen; ; bone marrow; ; right lung; ; right uterine tube; ; upper lobe of left lung; ; bone marrow cells; ; olfactory zone of nasal mucosa;
	Top expressed in
	granulocyte; ; right kidney; ; mesenteric lymph nodes; ; human kidney; ; tibiofemoral joint; ; spleen; ; stroma of bone marrow; ; yolk sac; ; proximal tubule; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; metal ion binding; protein binding; heme binding; protein heterodimerization activity; electron transfer activity; oxidoreductase activity; superoxide-generating NAD(P)H oxidase activity;
Cellular component	cytoplasm; endosome; phagocytic vesicle membrane; Golgi apparatus; membrane; plasma membrane; perinuclear endoplasmic reticulum; secretory granule; soma; NADPH oxidase complex; dendrite; apical plasma membrane; mitochondrion; nucleus; endoplasmic reticulum membrane; stress fiber; focal adhesion; specific granule membrane; tertiary granule membrane;
Biological process	positive regulation of reactive oxygen species biosynthetic process; cellular response to organic substance; positive regulation of phagocytosis; cytochrome complex assembly; response to interleukin-1; positive regulation of endothelial cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of release of sequestered calcium ion into cytosol; cellular response to tumor necrosis factor; cellular response to organic cyclic compound; negative regulation of glomerular filtration by angiotensin; smooth muscle hypertrophy; positive regulation of defense response to bacterium; cell redox homeostasis; reactive oxygen species metabolic process; superoxide anion generation; respiratory burst; regulation of blood pressure; cellular response to mechanical stimulus; positive regulation of cell growth; vascular endothelial growth factor receptor signaling pathway; response to nutrient levels; cellular response to gamma radiation; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; cellular response to amino acid stimulus; hydrogen peroxide biosynthetic process; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of superoxide anion generation; innate immune response; inflammatory response; positive regulation of mucus secretion; cellular response to glucose stimulus; superoxide metabolic process; positive regulation of smooth muscle cell proliferation; response to aldosterone; positive regulation of NAD(P)H oxidase activity; cellular response to L-glutamine; response to hypoxia; cellular response to angiotensin; response to activity; neutrophil degranulation; cellular response to oxidative stress; electron transport chain; positive regulation of blood pressure;
	Sources:Amigo / QuickGO
Orthologs
	1535
	13057
	ENSG00000051523
	ENSMUSG00000006519
	P13498
	Q61462
	NM_000101
	NM_001301284; NM_007806
	NP_000092
	NP_001288213; NP_031832
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome b-245 light chain is a protein that in humans is encoded by the CYBA gene involved in superoxide production and phagocytosis.

Cytochrome b-245 is composed of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit, which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), which is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.