CYP27A1

CYP27A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MFX
Identifiers
Aliases	CYP27A1, CP27, CTX, CYP27, cytochrome P450 family 27 subfamily A member 1
External IDs	OMIM: 606530; MGI: 88594; HomoloGene: 36040; GeneCards: CYP27A1; OMA:CYP27A1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,815,293 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,777,051 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; C1 segment; ; right adrenal cortex; ; tibial nerve; ; granulocyte; ; left adrenal gland; ; left adrenal cortex; ; upper lobe of left lung; ; mucosa of transverse colon; ; right uterine tube;
	Top expressed in
	left lobe of liver; ; muscle of thigh; ; esophagus; ; skeletal muscle tissue; ; medial head of gastrocnemius muscle; ; triceps brachii muscle; ; temporal muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	monooxygenase activity; iron ion binding; steroid hydroxylase activity; oxidoreductase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; vitamin D3 25-hydroxylase activity; cholesterol 26-hydroxylase activity; cholestanetriol 26-monooxygenase activity;
Cellular component	mitochondrial matrix; membrane; mitochondrial membranes; mitochondrion; mitochondrial inner membrane;
Biological process	sterol metabolic process; bile acid biosynthetic process; cholesterol catabolic process; calcitriol biosynthetic process from calciol; lipid metabolism; steroid biosynthetic process; steroid metabolic process; cholesterol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1593
	104086
	ENSG00000135929
	ENSMUSG00000026170
	Q02318
	Q9DBG1
	NM_000784
	NM_024264
	NP_000775
	NP_077226
	Wikidata
View/Edit Human	View/Edit Mouse

CYP27A1 is a gene encoding a cytochrome P450 oxidase, and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues where it is found within the mitochondria. It is most prominently involved in the biosynthesis of bile acids.