25-Hydroxyvitamin D 1-alpha-hydroxylase

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PubMed	articles
NCBI	proteins

calcidiol 1-monooxygenase
calcidiol 1-monooxygenase
Identifiers
EC no.	1.14.15.18
CAS no.	9081-36-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

CYP27B1
Identifiers
Aliases	CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1
External IDs	OMIM: 609506; MGI: 1098274; HomoloGene: 37139; GeneCards: CYP27B1; OMA:CYP27B1 - orthologs
EC number	1.14.15.18
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,768,986 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	126,888,875 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; metanephric glomerulus; ; body of pancreas; ; hair follicle; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left adrenal gland; ; human kidney; ; left adrenal cortex; ; right adrenal gland;
	Top expressed in
	morula; ; right kidney; ; embryo; ; convoluted tubule; ; embryo; ; proximal convoluted tubule; ; lip; ; human kidney; ; uterus; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; calcidiol 1-monooxygenase activity;
Cellular component	cytoplasm; membrane; mitochondrial membranes; mitochondrial outer membrane; mitochondrion;
Biological process	bone mineralization; response to vitamin D; calcium ion homeostasis; response to interferon-gamma; vitamin D metabolic process; regulation of bone mineralization; positive regulation of keratinocyte differentiation; G1 to G0 transition; response to estrogen; response to lipopolysaccharide; negative regulation of calcidiol 1-monooxygenase activity; decidualization; vitamin metabolic process; negative regulation of cell growth; calcitriol biosynthetic process from calciol; positive regulation of vitamin D 24-hydroxylase activity; vitamin D catabolic process; positive regulation of vitamin D receptor signaling pathway; calcium ion transport; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1594
	13115
	ENSG00000111012
	ENSMUSG00000006724
	O15528
	O35084
	NM_000785
	NM_010009
	NP_000776
	NP_034139
	Wikidata
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25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.

VD 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells, and bone (osteoblasts).