CYP2A13

CYP2A13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P85, 2PG5, 2PG6, 2PG7, 3T3S, 4EJG, 4EJH, 4EJI
Identifiers
Aliases	CYP2A13, CPAD, CYP2A, CYPIIA13, cytochrome P450 family 2 subfamily A member 13
External IDs	OMIM: 608055; MGI: 88597; HomoloGene: 85917; GeneCards: CYP2A13; OMA:CYP2A13 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,096,195 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	26,542,973 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; olfactory zone of nasal mucosa; ; Brodmann area 10; ; quadriceps femoris muscle; ; paraflocculus of cerebellum; ; mucosa of paranasal sinus; ; middle frontal gyrus; ; frontal pole; ; epithelium of bronchus; ; bronchial epithelial cell;
	Top expressed in
	proximal tubule; ; human kidney; ; right kidney; ; hepatobiliary system; ; liver; ; esophagus; ; respiratory epithelium; ; thymus; ; nasal epithelium; ; olfactory epithelium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxidoreductase activity; aromatase activity; arachidonic acid epoxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; coumarin 7-hydroxylase activity; steroid hydroxylase activity; monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle; cytoplasm;
Biological process	xenobiotic metabolic process; epoxygenase P450 pathway; coumarin metabolic process; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1553
	13087
	ENSG00000197838
	ENSMUSG00000005547
	Q16696
	P20852
	NM_000766
	NM_007812
	NP_000757
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.