CYP2D7

CYP2D7
Identifiers
Aliases	CYP2D7, CYP2D, CYP2D7AP, CYP2D7P1, CYP2D@, P450C2D, P450DB1, CYP2D7P, RNA40057, cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene), CYP2D6
External IDs	GeneCards: CYP2D7; OMA:CYP2D7 - orthologs
RNA expression pattern
	Top expressed in
	right lobe of liver; ; liver; ; muscle tissue; ; brain; ; testicle; ; myometrium; ; pituitary gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxidoreductase activity; aromatase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; monooxygenase activity; steroid hydroxylase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; mitochondrion; intracellular membrane-bounded organelle;
Biological process	xenobiotic metabolic process; arachidonic acid metabolic process; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1564
	n/a
	n/a
	n/a
	A0A087X1C5
	n/a
	NM_001348386; NM_001002910
	n/a
	NP_001335315
	n/a
	Wikidata
View/Edit Human

Cytochrome P450 2D7 (CYP2D7) is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP2D7 is a segregating pseudogene, meaning that some individuals may have an allele that encodes a functional enzyme, while others have an allele encoding a protein that is predicted to be non-functional. In this case, the functional allele is thought to be rare. This locus is part of a cluster of cytochrome P450 genes on chromosome 22.