CYP2E1

CYP2E1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z
Identifiers
Aliases	CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
External IDs	OMIM: 124040; MGI: 88607; HomoloGene: 68089; GeneCards: CYP2E1; OMA:CYP2E1 - orthologs
EC number	1.14.13.n7
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,561,220 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,354,900 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right hemisphere of cerebellum; ; body of pancreas; ; right frontal lobe; ; right uterine tube; ; skin of leg; ; skin of abdomen; ; endothelial cell; ; middle temporal gyrus; ; Brodmann area 9;
	Top expressed in
	left lobe of liver; ; tunica adventitia of aorta; ; white adipose tissue; ; right kidney; ; lactiferous gland; ; subcutaneous adipose tissue; ; intercostal muscle; ; human kidney; ; ankle joint; ; tunica media of zone of aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; arachidonic acid epoxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; enzyme binding; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; Hsp70 protein binding; Hsp90 protein binding;
Cellular component	organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; intrinsic component of endoplasmic reticulum membrane; Golgi membrane; endoplasmic reticulum; mitochondrion; cytoplasm; mitochondrial inner membrane;
Biological process	steroid metabolic process; epoxygenase P450 pathway; response to ozone; heterocycle metabolic process; response to organonitrogen compound; monoterpenoid metabolic process; xenobiotic metabolic process; response to ethanol; triglyceride metabolic process; carbon tetrachloride metabolic process; halogenated hydrocarbon metabolic process; benzene metabolic process; long-chain fatty acid biosynthetic process; response to bacterium; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1571
	13106
	ENSG00000130649
	ENSMUSG00000025479
	P05181
	Q05421
	NM_000773
	NM_021282
	NP_000764
	NP_067257
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign compounds in mammals.

While CYP2E1 itself carries out a relatively low number of these reactions (~4% of known P450-mediated drug oxidations), it and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of many toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.

CYP2E1 protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.