CYP4F3

CYP4F3
Identifiers
Aliases	CYP4F3, CPF3, CYP4F, LTB4H, cytochrome P450 family 4 subfamily F member 3, CYPIVF3
External IDs	OMIM: 601270; MGI: 2158641; HomoloGene: 73902; GeneCards: CYP4F3; OMA:CYP4F3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,662,825 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	33,166,376 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; trabecular bone; ; blood; ; bone marrow; ; kidney tubule; ; bone marrow cells; ; metanephric glomerulus; ; jejunal mucosa; ; gallbladder; ; human kidney;
	Top expressed in
	granulocyte; ; neural layer of retina; ; right kidney; ; yolk sac; ; duodenum; ; muscle of thigh; ; jejunum; ; left lobe of liver; ; lip; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; alpha-tocopherol omega-hydroxylase activity; tocopherol omega-hydroxylase activity; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; 20-hydroxy-leukotriene B4 omega oxidase activity; leukotriene-B4 20-monooxygenase activity; 20-aldehyde-leukotriene B4 20-monooxygenase activity;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	leukotriene metabolic process; lipid metabolism; icosanoid metabolic process; leukotriene B4 catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4051
	170716
	ENSG00000186529
	ENSMUSG00000024055
	Q08477
	n/a
	NM_000896; NM_001199208; NM_001199209; NM_001369696
	NM_130882
	NP_000887; NP_001186137; NP_001186138; NP_001356625
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 4F3, also leukotriene-B(4) omega-hydroxylase 2, is an enzyme that in humans is encoded by the CYP4F3 gene. CYP4F3 encodes two distinct enzymes, CYP4F3A and CYP4F3B, which originate from the alternative splicing of a single pre-mRNA precursor molecule; selection of either isoform is tissue-specific with CYP3F3A being expressed mostly in leukocytes and CYP4F3B mostly in the liver.