CYP7B1

CYP7B1
Identifiers
Aliases	CYP7B1, CBAS3, CP7B, SPG5A, cytochrome P450 family 7 subfamily B member 1
External IDs	OMIM: 603711; MGI: 104978; HomoloGene: 3544; GeneCards: CYP7B1; OMA:CYP7B1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	64,798,737 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	18,297,502 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; oral cavity; ; ventricular zone; ; skin of hip; ; corpus callosum; ; retinal pigment epithelium; ; C1 segment; ; tibia; ; epithelium of colon; ; liver;
	Top expressed in
	left lobe of liver; ; right kidney; ; renal calyx; ; efferent ductule; ; vas deferens; ; vestibular sensory epithelium; ; proximal tubule; ; sciatic nerve; ; human kidney; ; gallbladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; oxysterol 7-alpha-hydroxylase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	steroid metabolic process; positive regulation of epithelial cell proliferation; lipid metabolism; cholesterol metabolic process; prostate gland epithelium morphogenesis; sterol metabolic process; bile acid biosynthetic process; negative regulation of intracellular estrogen receptor signaling pathway; B cell chemotaxis; cholesterol homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	9420
	13123
	ENSG00000172817
	ENSMUSG00000039519
	O75881
	Q60991
	NM_004820; NM_001324112
	NM_007825
	NP_001311041; NP_004811
	NP_031851
	Wikidata
View/Edit Human	View/Edit Mouse

25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.