Cysteinyl leukotriene receptor 2

CYSLTR2
Identifiers
Aliases	CYSLTR2, CYSLT2, CYSLT2R, HG57, HPN321, KPG_011, hGPCR21, GPCR21, PSEC0146, cysteinyl leukotriene receptor 2
External IDs	OMIM: 605666; MGI: 1917336; HomoloGene: 10688; GeneCards: CYSLTR2; OMA:CYSLTR2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	48,711,226 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	73,286,554 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; monocyte; ; apex of heart; ; left adrenal cortex; ; granulocyte; ; right auricle of heart; ; left ventricle; ; lymph node; ; epithelium of colon; ; appendix;
	Top expressed in
	secondary oocyte; ; zygote; ; thymus; ; lumbar spinal ganglion; ; morula; ; granulocyte; ; blastocyst; ; right kidney; ; esophagus; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled peptide receptor activity; signal transducer activity; G protein-coupled receptor activity; leukotriene receptor activity; cysteinyl leukotriene receptor activity; galanin receptor activity;
Cellular component	integral component of plasma membrane; membrane; integral component of membrane; plasma membrane; cellular component;
Biological process	positive regulation of ERK1 and ERK2 cascade; immune response; phospholipase C-activating G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; leukotriene signaling pathway; signal transduction; positive regulation of cell death; positive regulation of angiogenesis; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57105
	70086
	ENSG00000152207
	ENSMUSG00000033470
	Q9NS75; Q5KU17
	Q920A1
NM_020377; NM_001308465; NM_001308467; NM_001308468; NM_001308469;
	NM_001308470; NM_001308471; NM_001308476; NM_001387012; NM_001387013; NM_001387014
	NM_001162412; NM_133720
NP_001295394; NP_001295396; NP_001295397; NP_001295398; NP_001295399;
	NP_001295400; NP_001295405; NP_065110; NP_001295394.1; NP_001295396.1; NP_001295397.1; NP_001295398.1; NP_001295399.1; NP_001295400.1; NP_001295405.1
	NP_001155884; NP_598481
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteinyl leukotriene receptor 2, also termed CYSLTR2, is a receptor for cysteinyl leukotrienes (LT) (see leukotrienes#Cysteinyl leukotrienes). CYSLTR2, by binding these cysteinyl LTs (CysLTs; viz, LTC4, LTD4, and to a much lesser extent, LTE4) contributes to mediating various allergic and hypersensitivity reactions in humans. However, the first discovered receptor for these CsLTs, cysteinyl leukotriene receptor 1 (CysLTR1), appears to play the major role in mediating these reactions.