Calpastatin

CAST
Identifiers
Aliases	CAST, BS-17, PLACK, calpastatin
External IDs	OMIM: 114090; MGI: 1098236; HomoloGene: 7658; GeneCards: CAST; OMA:CAST - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	96,779,595 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,956,929 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; bronchial epithelial cell; ; epithelium of colon; ; human penis; ; synovial joint; ; oral cavity; ; urethra; ; skin of thigh; ; mucosa of pharynx; ; skin of hip;
	Top expressed in
	spermatid; ; skin of external ear; ; granulocyte; ; seminiferous tubule; ; lip; ; esophagus; ; transitional epithelium of urinary bladder; ; muscle of thigh; ; stroma of bone marrow; ; triceps brachii muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity; protein binding; endopeptidase inhibitor activity; RNA binding; cadherin binding; calcium-dependent cysteine-type endopeptidase inhibitor activity; protease binding;
Cellular component	endoplasmic reticulum; membrane; cytosol;
Biological process	negative regulation of peptidase activity; negative regulation of type B pancreatic cell apoptotic process; inhibition of cysteine-type endopeptidase activity; presynaptic active zone organization;
	Sources:Amigo / QuickGO
Orthologs
	831
	12380
	ENSG00000153113
	ENSMUSG00000021585
	P20810
	P51125
NM_001042440; NM_001042441; NM_001042442; NM_001042443; NM_001042444;
	NM_001042445; NM_001042446; NM_001190442; NM_001284212; NM_001284213; NM_001750; NM_173060; NM_173061; NM_173062; NM_173063; NM_001330626; NM_001330627; NM_001330628; NM_001330629; NM_001330630; NM_001330631; NM_001330632; NM_001330633; NM_001330634; NM_001375317
NM_001301153; NM_001301155; NM_001301156; NM_001301157; NM_001301158;
	NM_001301160; NM_001301181; NM_009817
NP_001035905; NP_001035906; NP_001035907; NP_001035908; NP_001035909;
	NP_001035910; NP_001035911; NP_001177371; NP_001271141; NP_001271142; NP_001317555; NP_001317556; NP_001317557; NP_001317558; NP_001317559; NP_001317560; NP_001317561; NP_001317562; NP_001317563; NP_001741; NP_775083; NP_001362246
NP_001288082; NP_001288084; NP_001288085; NP_001288086; NP_001288087;
	NP_001288089; NP_001288110; NP_033947
	Wikidata
View/Edit Human	View/Edit Mouse

Calpastatin is a protein that in humans is encoded by the CAST gene.

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1–4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length natures of only some have been determined.