Caspase 1

CASP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA
Identifiers
Aliases	CASP1, ICE, IL1BC, P45, caspase 1
External IDs	OMIM: 147678; MGI: 96544; HomoloGene: 133272; GeneCards: CASP1; OMA:CASP1 - orthologs
EC number	3.4.22.36
Gene location (Human)
Chr.	Chromosome 11 (human)
End	105,035,250 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	5,307,290 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; jejunal mucosa; ; spleen; ; appendix; ; mucosa of ileum; ; duodenum; ; rectum; ; stromal cell of endometrium;
	Top expressed in
	Paneth cell; ; colon; ; ileum; ; left colon; ; jejunum; ; duodenum; ; epithelium of small intestine; ; granulocyte; ; crypt of lieberkuhn of small intestine; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; endopeptidase activity; peptidase activity; protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; hydrolase activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type endopeptidase activity involved in apoptotic process; kinase binding; cysteine-type endopeptidase activity; CARD domain binding; identical protein binding; cysteine-type endopeptidase activity involved in apoptotic signaling pathway;
Cellular component	NLRP3 inflammasome complex; cytoplasm; cytosol; NLRP1 inflammasome complex; extracellular region; AIM2 inflammasome complex; mitochondrion; IPAF inflammasome complex; protease inhibitor complex; protein-containing complex;
Biological process	cellular response to organic substance; response to ATP; response to hypoxia; response to bacterium; membrane hyperpolarization; pyroptosis; protein processing; toxin transport; proteolysis; cellular response to mechanical stimulus; response to lipopolysaccharide; regulation of autophagy; interleukin-1 beta production; mitochondrial depolarization; programmed necrotic cell death; signal transduction; apoptotic process; regulation of apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of inflammatory response; execution phase of apoptosis; cellular response to lipopolysaccharide; cellular response to interferon-gamma; protein autoprocessing; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; cytokine-mediated signaling pathway; cellular response to cytokine stimulus; apoptotic signaling pathway; positive regulation of interleukin-1 beta production;
	Sources:Amigo / QuickGO
Orthologs
	834
	12362
	ENSG00000137752
	ENSMUSG00000025888
	P29466
	P29452
NM_001223; NM_001257118; NM_001257119; NM_033292; NM_033293;
	NM_033294; NM_033295
	NM_009807
NP_001214; NP_001244047; NP_001244048; NP_150634; NP_150635;
	NP_150636; NP_150637
	NP_033937
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.