Caspase 10

CASP10
Identifiers
Aliases	CASP10, ALPS2, FLICE2, MCH4, Caspase 10, FLICE-2
External IDs	OMIM: 601762; HomoloGene: 50038; GeneCards: CASP10; OMA:CASP10 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,229,428 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; granulocyte; ; monocyte; ; rectum; ; buccal mucosa cell; ; spleen; ; bone marrow cells; ; blood; ; Achilles tendon; ; upper lobe of left lung;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	death effector domain binding; peptidase activity; cysteine-type peptidase activity; protein binding; hydrolase activity; ubiquitin protein ligase binding; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in apoptotic process;
Cellular component	ripoptosome; cytosol; CD95 death-inducing signaling complex; cytoplasm;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; apoptotic signaling pathway; cell surface receptor signaling pathway; proteolysis; apoptotic process; regulation of apoptotic process; execution phase of apoptosis; activation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	843
	n/a
	ENSG00000003400
	n/a
	Q92851
	n/a
NM_001206524; NM_001206542; NM_001230; NM_001306083; NM_032974;
	NM_032976; NM_032977
	n/a
NP_001193453; NP_001193471; NP_001221; NP_001293012; NP_116756;
	NP_116758; NP_116759
	n/a
	Wikidata
View/Edit Human

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.

That protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.