Cathepsin A

CTSA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IVY, 3BP4, 3BP7, 3BXN, 4AZ0, 4AZ3, 4CI9, 4CIA, 4CIB, 4MWS, 4MWT
Identifiers
Aliases	CTSA, GLB2, GSL, NGBE, PPCA, PPGB, cathepsin A
External IDs	OMIM: 613111; MGI: 97748; HomoloGene: 80163; GeneCards: CTSA; OMA:CTSA - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,898,949 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,682,952 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; mucosa of transverse colon; ; stromal cell of endometrium; ; monocyte; ; rectum; ; human kidney; ; gallbladder;
	Top expressed in
	stroma of bone marrow; ; decidua; ; calvaria; ; lip; ; right kidney; ; yolk sac; ; vestibular sensory epithelium; ; proximal tubule; ; skin of external ear; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; carboxypeptidase activity; enzyme activator activity; hydrolase activity; exo-alpha-sialidase activity; serine-type carboxypeptidase activity;
Cellular component	membrane; intracellular membrane-bounded organelle; nucleoplasm; lysosomal lumen; endoplasmic reticulum; lysosome; lumenal side of lysosomal membrane; extracellular exosome; extracellular region; azurophil granule lumen;
Biological process	regulation of protein stability; glycosphingolipid metabolic process; proteolysis; regulation of chaperone-mediated autophagy; proteolysis involved in cellular protein catabolic process; intracellular protein transport; positive regulation of catalytic activity; neutrophil degranulation; negative regulation of chaperone-mediated autophagy;
	Sources:Amigo / QuickGO
Orthologs
	5476
	19025
	ENSG00000064601
	ENSMUSG00000017760
	P10619
	P16675
	NM_001167594; NM_000308; NM_001127695
	NM_001038492; NM_008906
	NP_000299; NP_001121167; NP_001161066
	NP_001033581; NP_032932
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene. The enzyme is also known as Human Protective Protein. It is a lysosomal serine carboxypeptidase. The enzyme is a zymogen and must be processed to produce a 32 kDa and 20 kDa large and small subunit, respectively, to become catalytically active. Cathespin L can activate Cathepsin A in vitro.