Cathepsin G

CTSG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AU8, 1CGH, 1KYN, 1T32
Identifiers
Aliases	CTSG, CATG, CG, cathepsin G
External IDs	OMIM: 116830; MGI: 88563; HomoloGene: 105646; GeneCards: CTSG; OMA:CTSG - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,576,250 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,340,031 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow cells; ; triceps brachii muscle; ; gallbladder; ; skin of hip; ; testicle; ; monocyte; ; skin of leg; ; skin of abdomen; ; rectum;
	Top expressed in
	tibiofemoral joint; ; fetal liver hematopoietic progenitor cell; ; granulocyte; ; gastrula; ; bone marrow; ; decidua; ; ankle joint; ; body of femur; ; spleen; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; peptidase activity; protein binding; hydrolase activity; serine-type endopeptidase activity; serine-type peptidase activity;
Cellular component	extracellular matrix; plasma membrane; secretory granule; cell surface; extracellular exosome; nucleus; extracellular space; azurophil granule lumen; cytoplasmic stress granule; extracellular region; cytoplasm; collagen-containing extracellular matrix;
Biological process	extracellular matrix disassembly; proteolysis; angiotensin maturation; protein phosphorylation; response to lipopolysaccharide; positive regulation of immune response; defense response to bacterium; immune response; defense response to Gram-positive bacterium; antimicrobial humoral response; neutrophil degranulation; defense response to fungus; neutrophil-mediated killing of gram-positive bacterium;
	Sources:Amigo / QuickGO
Orthologs
	1511
	13035
	ENSG00000100448
	ENSMUSG00000040314
	P08311
	P28293
	NM_001911
	NM_007800
	NP_001902
	NP_031826
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin G is a protein that in humans is encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored in the azurophil granules, and also a member of the peptidase S1 protein family. Cathepsin G plays an important role in eliminating intracellular pathogens and breaking down tissues at inflammatory sites, as well as in anti-inflammatory response.