Cation-dependent mannose-6-phosphate receptor

M6PR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JUQ
Identifiers
Aliases	M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR, CD-mannose-6-phosphate receptor, cation dependent
External IDs	OMIM: 154540; MGI: 96904; HomoloGene: 31086; GeneCards: M6PR; OMA:M6PR - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,949,761 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,294,639 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; islet of Langerhans; ; spleen; ; rectum; ; lymph node; ; gallbladder; ; right lung; ; upper lobe of left lung; ; gastric mucosa;
	Top expressed in
	proximal tubule; ; right kidney; ; human kidney; ; ovary; ; placenta; ; adrenal gland; ; lung; ; ileum; ; spleen; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	mannose transmembrane transporter activity; mannose binding; transmembrane signaling receptor activity; protein binding; retromer complex binding; protein domain specific binding;
Cellular component	perinuclear region of cytoplasm; integral component of membrane; lysosomal membrane; endosome; late endosome; lysosome; integral component of plasma membrane; lytic vacuole; membrane; trans-Golgi network membrane; transport vesicle; plasma membrane; clathrin-coated vesicle membrane; retromer complex; trans-Golgi network; Golgi apparatus;
Biological process	mannose transmembrane transport; receptor-mediated endocytosis; endosome to lysosome transport; signal transduction; secretion of lysosomal enzymes; membrane organization; transport; protein targeting to lysosome; lysosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	4074
	17113
	ENSG00000003056
	ENSMUSG00000007458
	P20645
	P24668
	NM_001207024; NM_002355
	NM_010749
	NP_001193953; NP_002346
	NP_034879
	Wikidata
View/Edit Human	View/Edit Mouse

In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene.

The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for transport to the lysosome. Homologues of CD-MPR are found in all eukaryotes.