Cham Khalaf-e Isa Rural District
Cham Khalaf-e Isa Rural District 
    Persian: دهستان چم خلف عیسی  | |
|---|---|
| Coordinates: 30°26′15″N 49°42′12″E / 30.43750°N 49.70333°E | |
| Country | Iran | 
| Province | Khuzestan | 
| County | Hendijan | 
| District | Cham Khalaf-e Isa | 
| Capital | Zahreh | 
| Population  (2016)  | |
 • Total  | 2,524 | 
| Time zone | UTC+3:30 (IRST) | 
Cham Khalaf-e Isa Rural District (Persian: دهستان چم خلف عیسی) is in Cham Khalaf-e Isa District of Hendijan County, Khuzestan province, Iran. It is administered from the city of Zahreh.