Chitinase domain-containing protein 1

CHID1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BXW
Identifiers
Aliases	CHID1, SI-CLP, SICLP, GL008, chitinase domain containing 1
External IDs	OMIM: 615692; MGI: 1915288; HomoloGene: 12229; GeneCards: CHID1; OMA:CHID1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	915,058 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,119,770 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; body of pancreas; ; right testis; ; left testis; ; right lobe of liver; ; anterior pituitary; ; right adrenal cortex; ; islet of Langerhans; ; right uterine tube; ; left adrenal gland;
	Top expressed in
	spermatid; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; seminal vesicula; ; yolk sac; ; lacrimal gland; ; islet of Langerhans; ; lens; ; right kidney; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; oligosaccharide binding; chitinase activity; chitin binding;
Cellular component	late endosome; trans-Golgi network; extracellular exosome; membrane; nucleus; lysosome; extracellular region; extracellular space; lysosomal lumen;
Biological process	innate immune response; negative regulation of cytokine production involved in inflammatory response; immune system process; platelet degranulation; chitin catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	66005
	68038
	ENSG00000177830
	ENSMUSG00000025512
	Q9BWS9
	Q922Q9
	NM_001142674; NM_001142675; NM_001142676; NM_001142677; NM_023947
	NM_001142681; NM_026522; NM_001369350; NM_001369351; NM_001369352
	NP_001136146; NP_001136147; NP_001136148; NP_001136149; NP_076436
	NP_001136153; NP_080798; NP_001356279; NP_001356280; NP_001356281
	Wikidata
View/Edit Human	View/Edit Mouse

Chitinase domain-containing protein 1 (CHID1) is a highly conserved protein of unknown function located on the short (p) arm of chromosome 11 near the telomere. The protein has 27 introns, which allows for many isoforms of this gene. It has several aliases, the most common of which is Stabilin-1 interacting chitinase-like protein (SI-CLP). As indicated by the alias, CHID1 is known to interact with the protein STAB1. CHID1 is expressed ubiquitously at levels nearly 6 times the average gene, and is conserved very far back to organisms such as Caenorhabditis elegans and possibly some prokaryotes. This protein is known to have carbohydrate binding sites, which could be involved in carbohydrate catabolysis.