Cinanserin

Cinanserin
Clinical data
ATC code	none;
Identifiers
	IUPAC name (2E)-N-(2-{[3-(dimethylamino)propyl]thio}phenyl)-3-phenylacrylamide;
CAS Number	1166-34-3 ;
PubChem CID	5475158;
ChemSpider	4584027 ;
UNII	KI6J9OY7A3;
ChEBI	CHEBI:145999;
ChEMBL	ChEMBL18786 ;
CompTox Dashboard (EPA)	DTXSID30859588 DTXSID7045653, DTXSID30859588 ;
ECHA InfoCard	100.220.552
Chemical and physical data
Formula	C20H24N2OS
Molar mass	340.49 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCCSC1=CC=CC=C1NC(=O)\C=C\C2=CC=CC=C2;
	InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+ ; Key:RSUVYMGADVXGOU-BUHFOSPRSA-N ;
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Cinanserin (INN) is a 5-HT_2A and 5-HT_2C receptor antagonist which was discovered in the 1960s. It showed about 50-fold higher affinity for the serotonin 5-HT_2A receptor over the serotonin 5-HT_2C receptor and had very low affinity for the serotonin 5-HT₁ receptors.

The molecule is an inhibitor of the 3C-like protease of SARS-CoV-1 and SARS-CoV-2.

Clinical data

ATC code	none
Identifiers
IUPAC name (2E)-N-(2-{[3-(dimethylamino)propyl]thio}phenyl)-3-phenylacrylamide
CAS Number	1166-34-3^Y
PubChem CID	5475158
ChemSpider	4584027^N
UNII	KI6J9OY7A3
ChEBI	CHEBI:145999
ChEMBL	ChEMBL18786^N
CompTox Dashboard (EPA)	DTXSID30859588 DTXSID7045653, DTXSID30859588
ECHA InfoCard	100.220.552
Chemical and physical data
Formula	C₂₀H₂₄N₂OS
Molar mass	340.49 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCCSC1=CC=CC=C1NC(=O)\C=C\C2=CC=CC=C2
InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+^N Key:RSUVYMGADVXGOU-BUHFOSPRSA-N^N
^NY (what is this?) (verify)