Clobetasol propionate

Clobetasol propionate
Clinical data
Pronunciation	/kloʊˈbeɪtəsɒl/
Trade names	Dermovate, Temovate, Clovate, others
AHFS/Drugs.com	Monograph
License data	US DailyMed: Clobetasol propionate;
Pregnancy; category	AU: B3;
Routes of; administration	Topical
ATC code	D07AD01 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Identifiers
	IUPAC name [17-(2'-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;
CAS Number	25122-46-7 ;
PubChem CID	32798;
IUPHAR/BPS	7062;
DrugBank	DB01013 ;
ChemSpider	30399 ;
UNII	779619577M;
KEGG	D01272;
ChEBI	CHEBI:31414 ;
ChEMBL	ChEMBL1159650 ;
CompTox Dashboard (EPA)	DTXSID6045907 ;
ECHA InfoCard	100.042.380
Chemical and physical data
Formula	C25H32ClFO5
Molar mass	466.97 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClCC(=O)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C;
	InChI InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1 ; Key:CBGUOGMQLZIXBE-XGQKBEPLSA-N ;
	(verify)

Clobetasol propionate is a corticosteroid that is used to treat skin conditions such as eczema, contact dermatitis, seborrheic dermatitis, steroid responsive dermatosis, and psoriasis (including scalp and plaque-type). It is applied to the skin as a cream, foam, gel, liquid, solution, ointment, or shampoo. Clobetasol propionate is a propionate ester of the corticosteroid clobetasol.

Common side effects include skin irritation, dry skin, redness, pimples, and telangiectasia. Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome. Use in pregnancy and breastfeeding is of unclear safety. Clobetasol is believed to work by activating steroid receptors.

Clobetasol propionate was patented in 1968 and came into medical use in 1978. It is available as a generic medication. In 2022, it was the 156th most commonly prescribed medication in the United States, with more than 3 million prescriptions.