Clorazepate

Clorazepate
Clinical data
Trade names	Tranxene, Tranxilium, Novo-Clopate
Other names	Clorazepate dipotassium
AHFS/Drugs.com	Monograph
MedlinePlus	a682052
Routes of; administration	Oral
ATC code	N05BA05 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); UK: Class C; US: Schedule IV;
Pharmacokinetic data
Bioavailability	91%
Metabolism	Hepatic
Elimination half-life	48 hours
Excretion	Renal
Identifiers
	IUPAC name (RS)-7-Chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid;
CAS Number	23887-31-2 ; 57109-90-7 (potassium salt);
PubChem CID	2809;
IUPHAR/BPS	7548;
DrugBank	DB00628 ;
ChemSpider	2707 ;
UNII	D51WO0G0L4;
KEGG	C06921 ; as potassium: D00694;
ChEMBL	ChEMBL1201305 ;
CompTox Dashboard (EPA)	DTXSID20863674 ;
ECHA InfoCard	100.041.737
Chemical and physical data
Formula	C16H11ClN2O3
Molar mass	314.73 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O;
	InChI InChI=1S/C16H11ClN2O3/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12/h1-8,14H,(H,18,20)(H,21,22) ; Key:XDDJGVMJFWAHJX-UHFFFAOYSA-N ;
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Clorazepate, sold under the brand name Tranxene among others, is a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. Clorazepate is an unusually long-lasting benzodiazepine and serves as a prodrug for the equally long-lasting desmethyldiazepam, which is rapidly produced as an active metabolite. Desmethyldiazepam is responsible for most of the therapeutic effects of clorazepate.

It was patented in 1965 and approved for medical use in 1967.