Clotiazepam

Clotiazepam
Clinical data
Trade names	Veratran, Rize, Clozan
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, sublingual, liquid drops
ATC code	N05BA21 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); UK: Class C; US: Schedule IV;
Pharmacokinetic data
Bioavailability	~90%
Metabolism	Hepatic
Elimination half-life	4 hours
Excretion	Renal
Identifiers
	IUPAC name 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one;
CAS Number	33671-46-4 ;
PubChem CID	2811;
DrugBank	DB01559 ;
ChemSpider	2709 ;
UNII	ZCN055599V;
KEGG	D01328 ;
ChEMBL	ChEMBL1697737 ;
CompTox Dashboard (EPA)	DTXSID0022852 ;
ECHA InfoCard	100.046.920
Chemical and physical data
Formula	C16H15ClN2OS
Molar mass	318.82 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC1=C(C2=NCC(N(C)C3=C2C=C(CC)S3)=O)C=CC=C1;
	InChI InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3 ; Key:CHBRHODLKOZEPZ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Clotiazepam (marketed under brand name Clozan, Distensan, Trecalmo, Rize, Rizen and Veratran) is a thienodiazepine drug which is a benzodiazepine analog. The clotiazepam molecule differs from benzodiazepines in that the benzene ring has been replaced by a thiophene ring. It possesses anxiolytic, skeletal muscle relaxant, anticonvulsant, sedative properties. Stage 2 NREM sleep is significantly increased by clotiazepam.