Amoxicillin/clavulanic acid

Amoxicillin/clavulanic acid
Combination of
Amoxicillin	Penicillin antibiotic
Clavulanic acid	Beta-lactamase inhibitor
Clinical data
Trade names	Augmentin, Clavulin, Amoclan, others
Other names	Co-amoxiclav; Amox-clav
AHFS/Drugs.com	Monograph
MedlinePlus	a685024
License data	US DailyMed: Amoxicillin clavulanate;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth, intravenous
ATC code	J01CR02 (WHO) QJ01CR02 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Identifiers
CAS Number	74469-00-4; 74428-36-7;
PubChem CID	6435924;
ChemSpider	4940608;
KEGG	D06485;
ChEMBL	ChEMBL1697738;
CompTox Dashboard (EPA)	DTXSID40225477 ;
Chemical and physical data
Formula	C24H27KN4O10S
Molar mass	602.66 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C.C1C2N(C1=O)C(C(=CCO)O2)C(=O)[O-].[K+];
	InChI InChI=DWHGNUUWCJZQHO-ZVDZYBSKSA-M; Key:1S/C16H19N3O5S.C8H9NO5.K/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);1,6-7,10H,2-3H2,(H,12,13);/q;;+1/p-1/b;4-1-;/t9-,10-,11+,14-;6-,7-;/m11./s1;
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Amoxicillin/clavulanic acid, also known as co-amoxiclav or amox-clav, sold under the brand name Augmentin, among others, is an antibiotic medication used for the treatment of a number of bacterial infections. It is a combination consisting of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. It is specifically used for otitis media, streptococcal pharyngitis, pneumonia, cellulitis, urinary tract infections, and animal bites. It can be administered orally or intravenously.

Common side effects include diarrhea, vomiting, and allergic reactions. It also increases the risk of yeast infections, headaches, and blood clotting problems. It is not recommended in people with a history of a penicillin allergy. It is relatively safe for use during pregnancy.

Amoxicillin/clavulanic acid was approved for medical use in the United States in 1984. It is on the World Health Organization's List of Essential Medicines. The World Health Organization classifies amoxicillin/clavulanic-acid as critically important for human medicine. It is available as a generic medication. In 2022, it was the 96th most commonly prescribed medication in the United States, with more than 6 million prescriptions.