Factor XIII
| coagulation factor XIII, A1 polypeptide | |||||||
|---|---|---|---|---|---|---|---|
Inactive A1 peptide homodimer with all of the domains and main catalytic residues shown with different colors. | |||||||
| Identifiers | |||||||
| Symbol | F13A1 | ||||||
| Alt. symbols | F13A | ||||||
| NCBI gene | 2162 | ||||||
| HGNC | 3531 | ||||||
| OMIM | 134570 | ||||||
| RefSeq | NM_000129 | ||||||
| UniProt | P00488 | ||||||
| Other data | |||||||
| EC number | 2.3.2.13 | ||||||
| Locus | Chr. 6 p24.2-p23 | ||||||
| |||||||
| coagulation factor XIII, B polypeptide | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | F13B | ||||||
| NCBI gene | 2165 | ||||||
| HGNC | 3534 | ||||||
| OMIM | 134580 | ||||||
| RefSeq | NM_001994 | ||||||
| UniProt | P05160 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q31-q32.1 | ||||||
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Factor XIII, or fibrin stabilizing factor, is a plasma protein and zymogen. It is activated by thrombin to factor XIIIa which crosslinks fibrin in coagulation. Deficiency of XIII worsens clot stability and increases bleeding tendency.
Human XIII is a heterotetramer. It consists of 2 enzymatic A peptides and 2 non-enzymatic B peptides. XIIIa is a dimer of activated A peptides.