Colestipol

Colestipol
Clinical data
Trade names	Colestid, Cholestabyl
AHFS/Drugs.com	Monograph
MedlinePlus	a682157
Routes of; administration	Oral (suspension or tablets)
ATC code	C10AC02 (WHO) ;
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	None
Excretion	Faeces, in complex with bile acids
Identifiers
	IUPAC name Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane;
CAS Number	26658-42-4 ; 37296-80-3 (HCl);
PubChem CID	62816;
DrugBank	DB00375 ;
ChemSpider	none;
UNII	K50N755924;
KEGG	C06925 ;
ChEMBL	ChEMBL1201678 ;
CompTox Dashboard (EPA)	DTXSID00965206 DTXSID901009549, DTXSID00965206 ;
ECHA InfoCard	100.123.044
Chemical and physical data
Formula	(C4H10N3)m(C3H6O)n
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Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL). It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.

Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.