The Cottbus–Frankfurt (Oder) railway is a single-track main line in the German state of Brandenburg, which was originally built and operated by the Cottbus-Großenhain Railway Company (German: Cottbus-Großenhainer Eisenbahn-Gesellschaft, CGE) and directly connects the two cities to each other. It runs from Cottbus via Peitz to Frankfurt (Oder). Only the section between Grunow and Frankfurt and a short section near Cottbus are still in operation. Trains running over the line now use the line to Guben and continue on the line of the former Lower Silesian-Mark Railway (Niederschlesisch-Märkische Eisenbahn).