Cubam
| amnionless homolog (mouse) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AMN | ||||||
| Alt. symbols | PRO1028 | ||||||
| NCBI gene | 81693 | ||||||
| HGNC | 14604 | ||||||
| OMIM | 605799 | ||||||
| RefSeq | NM_030943 | ||||||
| UniProt | Q9BXJ7 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q32.32 | ||||||
| |||||||
| cubilin (intrinsic factor-cobalamin receptor) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CUBN | ||||||
| Alt. symbols | MGA1 | ||||||
| NCBI gene | 8029 | ||||||
| HGNC | 2548 | ||||||
| OMIM | 602997 | ||||||
| RefSeq | NM_001081 | ||||||
| UniProt | O60494 | ||||||
| Other data | |||||||
| Locus | Chr. 10 p12 | ||||||
| |||||||
Cubam, is the term used to refer to a multi-ligand receptor located in the terminal ileum, specializing in absorption of vitamin B12. Cubam is essentially composed of amnionless (AMN), and cubilin. Cubilin is essential as a cell receptor recognizing the "vitamin B12-intrinsic factor" complex, whereas amnionless is more involved in the receptor mediated endocytosis of the complex.