Curtius rearrangement

Curtius rearrangement
Named after Theodor Curtius
Reaction type Rearrangement reaction
Identifiers
Organic Chemistry Portal curtius-rearrangement
RSC ontology ID RXNO:0000054

The Curtius rearrangement (or Curtius reaction or Curtius degradation), first defined by Theodor Curtius in 1885, is the thermal decomposition of an acyl azide to an isocyanate with loss of nitrogen gas. The isocyanate then undergoes attack by a variety of nucleophiles such as water, alcohols and amines, to yield a primary amine, carbamate or urea derivative respectively. Several reviews have been published.

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