Cyclin-dependent kinase 4

CDK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK
Identifiers
Aliases	CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
External IDs	OMIM: 123829; MGI: 88357; HomoloGene: 55429; GeneCards: CDK4; OMA:CDK4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,756,013 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; stromal cell of endometrium; ; right adrenal gland; ; right ovary; ; smooth muscle tissue; ; right adrenal cortex; ; left ovary; ; left adrenal gland; ; left adrenal cortex;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; cyclin-dependent protein kinase holoenzyme complex; nuclear membrane; membrane; transcription regulator complex; bicellular tight junction; nucleoplasm; nucleolus; perinuclear region of cytoplasm; chromatin; nucleus; cyclin D2-CDK4 complex; protein-containing complex;
Biological process	phosphorylation; response to testosterone; positive regulation of fibroblast proliferation; response to hyperoxia; positive regulation of translation; regulation of cell cycle; cell division; protein phosphorylation; lens development in camera-type eye; regulation of cell population proliferation; response to lead ion; circadian rhythm; animal organ regeneration; positive regulation of cell population proliferation; positive regulation of cell size; positive regulation of apoptotic process; regulation of gene expression; cell cycle; positive regulation of G2/M transition of mitotic cell cycle; response to toxic substance; positive regulation of cell cycle; signal transduction; multicellular organism development; response to organic substance; cellular response to insulin stimulus; regulation of multicellular organism growth; regulation of insulin receptor signaling pathway; regulation of lipid biosynthetic process; regulation of lipid catabolic process; adipose tissue development; cellular response to lipopolysaccharide; cellular response to interleukin-4; cellular response to phorbol 13-acetate 12-myristate; cellular response to ionomycin; transcription initiation from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1019
	12567
	ENSG00000135446
	n/a
	P11802
	P30285
	NM_052984; NM_000075
	NM_009870; NM_001355005
	NP_000066
	NP_034000; NP_001341934
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member of the cyclin-dependent kinase family, a group of serine/threonine kinases which regulate the cell cycle. CDK4 regulates the G1/S transition by contributing to the phosphorylation of retinoblastoma (RB) protein, which leads to the release of protein factors like E2F1 that promote S-phase progression. It is regulated by cyclins like cyclin D proteins, regulatory kinases, and cyclin kinase inhibitors (CKIs). Dysregulation of the CDK4 pathway is common in many cancers, and CDK4 is a new therapeutic target in cancer treatment.