Cysteine-rich secretory protein
| Crisp domain (CRD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Crisp | ||||||||
| Pfam | PF08562 | ||||||||
| Pfam clan | CL0213 | ||||||||
| InterPro | IPR013871 | ||||||||
| |||||||||
Cysteine-rich secretory proteins, often abbreviated as CRISPs, are a group of glycoproteins. They are a subgroup of the CRISP, antigen 5 and Pr-1 (CAP) protein superfamily and also contain a domain related to the ShK toxins. They are substantially implicated in the functioning of the mammalian reproductive system. CRISPs are also found in a variety of snake venoms where they inhibit both smooth muscle contraction and cyclic nucleotide-gated ion channels.