Cytochrome c oxidase subunit 2

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Cytochrome c oxidase subunit II, transmembrane domain
Cytochrome c oxidase subunit II, transmembrane domain
	Bacterial cytochrome c oxidase complex. Subunit II indicated by blue.
Identifiers
Symbol	COX2_TM
Pfam	PF02790
InterPro	IPR011759
PROSITE	PDOC00075
SCOP2	1occ / SCOPe / SUPFAM
TCDB	3.D.4
OPM superfamily	4
OPM protein	1v55
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

COX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VRJ
Identifiers
Aliases	COX2, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II
External IDs	OMIM: 516040; MGI: 102503; HomoloGene: 5017; GeneCards: COX2; OMA:COX2 - orthologs
Gene location (Human)
Chr.	Mitochondrial DNA (human)
End	8,269 bp
Gene location (Mouse)
Chr.	Mitochondrial DNA (mouse)
End	7,696 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; putamen; ; caudate nucleus; ; right frontal lobe; ; nucleus accumbens; ; right hemisphere of cerebellum; ; hippocampus proper; ; substantia nigra; ; muscle layer of sigmoid colon; ; Hypothalamus;
	Top expressed in
	ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; esophagus; ; zone of skin; ; ovary; ; epiblast; ; jejunum; ; right kidney; ; proximal tubule; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; copper ion binding; oxidoreductase activity; cytochrome-c oxidase activity;
Cellular component	respiratory chain complex IV; respirasome; integral component of membrane; mitochondrion; membrane; extracellular exosome; mitochondrial respiratory chain complex IV; mitochondrial inner membrane;
Biological process	electron transport chain; response to cold; lactation; proton transmembrane transport; mitochondrial electron transport, cytochrome c to oxygen; ATP synthesis coupled electron transport; positive regulation of hydrogen peroxide biosynthetic process; positive regulation of necrotic cell death; positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4513
	17709
	ENSG00000198712
	ENSMUSG00000064354
	P00403
	P00405
	n/a
	n/a
	n/a
	NP_904331
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome C oxidase subunit II, periplasmic domain

Identifiers

Symbol

COX2

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Cytochrome c oxidase II is a protein in eukaryotes that is encoded by the MT-CO2 gene. Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase. It is also one of the three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratory complex IV.