D-alanine—(R)-lactate ligase

D-Alanine—(R)-lactate ligase
Identifiers
EC no.6.1.2.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

D-alanine—(R)-lactate ligase (EC 6.1.2.1, VanA, VanB, VanD) is an enzyme with systematic name D-alanine:(R)-lactate ligase (ADP-forming). This enzyme catalyses the following chemical reaction

D-alanine + (R)-lactate + ATP D-alanyl-(R)-lactate + ADP + phosphate

The product of this enzyme can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide.