DAB2

DAB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LSW
Identifiers
Aliases	DAB2, DOC-2, DOC2, clathrin adaptor protein, DAB adaptor protein 2
External IDs	OMIM: 601236; MGI: 109175; HomoloGene: 1026; GeneCards: DAB2; OMA:DAB2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	39,462,300 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	6,470,193 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; corpus epididymis; ; tendon of biceps brachii; ; placenta; ; synovial joint; ; Achilles tendon; ; right adrenal cortex; ; human kidney; ; synovial membrane; ; left adrenal gland;
	Top expressed in
	yolk sac; ; stroma of bone marrow; ; efferent ductule; ; right kidney; ; zygote; ; human kidney; ; dermis; ; adrenal gland; ; proximal tubule; ; secondary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	clathrin adaptor activity; protein C-terminus binding; protein binding; cargo receptor activity; SMAD binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; membrane; focal adhesion; plasma membrane; lysosomal membrane; nucleolus; clathrin-coated vesicle membrane; clathrin-coated pit; extracellular exosome; cytoplasmic vesicle; clathrin-coated vesicle; fibrillar center; cytosol;
Biological process	positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; positive regulation of protein phosphorylation; endocytosis; positive regulation of cell migration; positive regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; Wnt signaling pathway; negative regulation of protein binding; positive regulation of epithelial to mesenchymal transition; leading edge cell differentiation; multicellular organism development; positive regulation of transcription, DNA-templated; positive regulation of endocytosis; negative regulation of protein localization to plasma membrane; positive regulation of clathrin-dependent endocytosis; protein transport; positive regulation of early endosome to late endosome transport; integrin-mediated signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; cell population proliferation; negative regulation of transcription, DNA-templated; negative regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of SMAD protein signal transduction; apoptotic process; receptor-mediated endocytosis; membrane organization; transport;
	Sources:Amigo / QuickGO
Orthologs
	1601
	13132
	ENSG00000153071
	ENSMUSG00000022150
	P98082
	P98078
	NM_001343; NM_001244871
	NM_001008702; NM_001037905; NM_001102400; NM_023118; NM_001310446
	NP_001231800; NP_001334
	NP_001008702; NP_001032994; NP_001095870; NP_001297375; NP_075607
	Wikidata
View/Edit Human	View/Edit Mouse

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.