Dishevelled binding antagonist of beta catenin 1

DACT1
Identifiers
Aliases	DACT1, DAPPER, DAPPER1, DPR1, FRODO, HDPR1, THYEX3, dishevelled binding antagonist of beta catenin 1, TBS2
External IDs	OMIM: 607861; MGI: 1891740; HomoloGene: 9613; GeneCards: DACT1; OMA:DACT1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	58,648,321 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	71,366,881 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; gallbladder; ; ganglionic eminence; ; ascending aorta; ; left coronary artery; ; tibial nerve; ; cerebellar cortex; ; cerebellar hemisphere; ; cartilage tissue; ; Descending thoracic aorta;
	Top expressed in
	condyle; ; sciatic nerve; ; trigeminal ganglion; ; stroma of kidney; ; fossa; ; medial ganglionic eminence; ; genital tubercle; ; tail of embryo; ; abdominal wall; ; endocardial cushion;
	More reference expression data
	n/a
Gene ontology
Molecular function	beta-catenin binding; protein kinase A binding; histone deacetylase binding; delta-catenin binding; protein binding; protein kinase C binding;
Cellular component	cytoplasm; cytosol; synapse; nucleoplasm; cell junction; nucleus; beta-catenin destruction complex;
Biological process	regulation of protein stability; positive regulation of protein catabolic process; regulation of Wnt signaling pathway, planar cell polarity pathway; negative regulation of Wnt signaling pathway; regulation of nodal signaling pathway; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; negative regulation of protein binding; embryonic hindgut morphogenesis; nervous system development; negative regulation of G1/S transition of mitotic cell cycle; multicellular organism development; positive regulation of Wnt signaling pathway; negative regulation of JNK cascade; negative regulation of beta-catenin-TCF complex assembly; neural tube development; positive regulation of protein binding; negative regulation of canonical Wnt signaling pathway; regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; regulation of Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	51339
	59036
	ENSG00000165617
	ENSMUSG00000044548
	Q9NYF0
	Q8R4A3
	NM_001079520; NM_016651
	NM_001190466; NM_021532
	NP_001072988; NP_057735
	NP_001177395; NP_067507
	Wikidata
View/Edit Human	View/Edit Mouse

Dishevelled binding antagonist of beta catenin 1 (Dact1, previously known as Dapper, Dpr1, Frodo) is a protein that in humans is encoded by the DACT1 gene. Dact1 was originally described in 2002 as a negative regulator of Wnt signaling by binding and destabilizing Dishevelled. More recent investigation into the molecular function of Dact1 has identified its principal role in the cell as a scaffold to generate membrane-less biomolecular condensates through liquid-liquid phase separation. Mutations in the phase-separating regions of Dact1 lead to Townes-Brock Syndrome 2 while its overexpression is associated with bone metastasis.