DAP3

DAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Identifiers
Aliases	DAP3, DAP-3, MRP-S29, MRPS29, bMRP-10, death associated protein 3, S29mt
External IDs	OMIM: 602074; MGI: 1929538; HomoloGene: 3404; GeneCards: DAP3; OMA:DAP3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,739,010 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,858,488 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; epithelium of colon; ; rectum; ; lymph node; ; islet of Langerhans; ; granulocyte; ; apex of heart; ; buccal mucosa cell; ; monocyte; ; anterior pituitary;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; ventricular zone; ; thymus; ; facial motor nucleus; ; yolk sac; ; right ventricle; ; primary oocyte; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding; nucleotide binding; GTP binding;
Cellular component	small ribosomal subunit; mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrion; mitochondrial small ribosomal subunit; nucleoplasm;
Biological process	apoptotic signaling pathway; mitochondrial translational elongation; mitochondrial translational termination; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	7818
	65111
	ENSG00000132676
	ENSMUSG00000068921
	P51398
	Q9ER88
	NM_001199849; NM_001199850; NM_001199851; NM_004632; NM_033657
	NM_001164533; NM_022994; NM_001368419
	NP_001186778; NP_001186779; NP_001186780; NP_004623; NP_387506
	NP_001158005; NP_075370; NP_001355348
	Wikidata
View/Edit Human	View/Edit Mouse

28S ribosomal protein S29, mitochondrial, also known as death-associated protein 3 (DAP3), is a protein that in humans is encoded by the DAP3 gene on chromosome 1. This gene encodes a 28S subunit protein of the mitochondrial ribosome (mitoribosome) and plays key roles in translation, cellular respiration, and apoptosis. Moreover, DAP3 is associated with cancer development, but has been observed to aid some cancers while suppressing others.