DAPK2

DAPK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WMK, 1WRZ, 1Z9X, 1ZUZ, 1ZWS, 2A27, 2A2A, 2CKE
Identifiers
Aliases	DAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDs	OMIM: 616567; MGI: 1341297; HomoloGene: 74940; GeneCards: DAPK2; OMA:DAPK2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,072,033 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,272,242 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right auricle of heart; ; right lung; ; gastrocnemius muscle; ; muscle of thigh; ; upper lobe of left lung; ; left ventricle; ; blood; ; sural nerve;
	Top expressed in
	muscle of thigh; ; membranous bone; ; body of femur; ; lumbar spinal ganglion; ; Dermatocranium; ; maxilla; ; lip; ; right lung; ; right lung lobe; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calmodulin binding; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; ATP binding;
Cellular component	cytoplasm; autophagosome lumen; cytoplasmic vesicle; Golgi apparatus; intracellular membrane-bounded organelle; nucleus;
Biological process	regulation of apoptotic process; intracellular signal transduction; regulation of intrinsic apoptotic signaling pathway; phosphorylation; protein phosphorylation; positive regulation of eosinophil chemotaxis; regulation of autophagy; anoikis; positive regulation of neutrophil chemotaxis; protein autophosphorylation; neutrophil migration; apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23604
	13143
	ENSG00000035664
	ENSMUSG00000032380
	Q9UIK4
	Q8VDF3
NM_014326; NM_001363730; NM_001384997; NM_001384998; NM_001384999;
	NM_001385000
	NM_010019
	NP_055141; NP_001350659
	NP_034149; NP_001391612
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Gene overexpression induces cell apoptosis. It uses multiple polyadenylation sites.

The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.