DARS (gene)

DARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J15
Identifiers
Aliases	DARS1, HBSL, aspRS, aspartyl-tRNA synthetase, aspartyl-tRNA synthetase 1, DARS
External IDs	OMIM: 603084; MGI: 2442544; HomoloGene: 1032; GeneCards: DARS1; OMA:DARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	135,986,100 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	128,345,105 bp
RNA expression pattern
	Top expressed in
	oocyte; ; pericardium; ; cartilage tissue; ; ventricular zone; ; secondary oocyte; ; parotid gland; ; beta cell; ; nipple; ; vena cava; ; seminal vesicula;
	Top expressed in
	yolk sac; ; spermatocyte; ; epiblast; ; ventricular zone; ; embryo; ; granulocyte; ; migratory enteric neural crest cell; ; spermatid; ; embryo; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	aspartate-tRNA ligase activity; aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; ATP binding; aminoacylase activity; nucleic acid binding; RNA binding;
Cellular component	extracellular exosome; membrane; cytoplasm; aminoacyl-tRNA synthetase multienzyme complex; cytosol; synapse;
Biological process	tRNA aminoacylation for protein translation; protein biosynthesis; aspartyl-tRNA aminoacylation; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	1615
	226414
	ENSG00000115866
	ENSMUSG00000026356
	P14868
	Q922B2
	NM_001349; NM_001293312
	NM_145507; NM_177445
	NP_001280241; NP_001340
	NP_663482; NP_803228
	Wikidata
View/Edit Human	View/Edit Mouse

Aspartyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the DARS gene.

Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase charges its cognate tRNA with aspartate during protein biosynthesis.